Inna Smalley

This study uses single-cell RNA-sequencing to show that aging promotes KRAS-driven lung adenocarcinoma evolution toward a stem-like state through age-related changes in the tumor microenvironment.

spatialGE simplifies spatial transcriptomics analysis by providing a user-friendly web interface for non-programmers, enabling tasks like quality control, domain detection, and spatial analysis.

This study uses spatial transcriptomics to identify a tumor-promoting role of meningeal stroma in melanoma leptomeningeal disease and shows that targeting SERPINA3 or its downstream pathway can restore drug sensitivity.

This study identifies branched-chain keto acid accumulation in leptomeningeal disease CSF, showing immune suppression and neurodegeneration, and shows that reducing BCKA improves outcomes in mouse models.

The paper introduces spatialGE, a software tool for quantifying and visualizing tumor microenvironment heterogeneity using spatial transcriptomics data.