Jeffrey D. Mandell

The paper shows early NOTCH1 mutations are selected in normal tissue but suppress later cancer driver mutations through epistasis, highlighting stage-specific mutation effects in esophageal cancer.

This study analyzes the evolutionary dynamics of driver mutations during endometrial hyperplasia to carcinoma progression, revealing differences in selection pressures and epistatic interactions between mutation pairs.

This study quantifies mutation rates, selection coefficients, and epistatic interactions across prostate cancer stages, revealing dynamic selective pressures and therapeutic implications.

This study examines the role of noncoding variation in autism spectrum disorder using whole genome sequencing of 2,076 genomes, finding no significant association after correction for multiple testing.