Jeffrey Nicholas Fisk

The paper shows early NOTCH1 mutations are selected in normal tissue but suppress later cancer driver mutations through epistasis, highlighting stage-specific mutation effects in esophageal cancer.

This study analyzes the evolutionary dynamics of driver mutations during endometrial hyperplasia to carcinoma progression, revealing differences in selection pressures and epistatic interactions between mutation pairs.

The paper analyzes how phylogenetic signal, noise, and bias affect tree resolution in phylogenomics and shows their divergent scaling properties with character sampling.

TyCHE improves time-resolved lineage tracing by accounting for heterogeneous mutation rates, applied to memory B cells, germinal centers, gliomas, and bacterial infections.

This study quantifies mutation rates, selection coefficients, and epistatic interactions across prostate cancer stages, revealing dynamic selective pressures and therapeutic implications.

The paper identifies distinct chromatin contexts for p53 binding sites in normal and cancer cells, revealing differences in histone marks, DNA methylation, and nucleosome occupancy.