Author

M. E. Sharpe

Paul Scherrer InstituteORCID 0000-0002-3880-7438Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

M. E. Sharpe1 paper

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

A. Mac SweeneyiD· 1 shared A. MetziD· 1 shared Aina E. CoheniD· 1 shared Alain ChamboveyiD· 1 shared Alexander DeitersiD· 1 shared Brisa Caroline Alves ChagasiD· 1 shared Céline Potot· 1 shared Chia‐Ying HuangiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiophysics

A. Mac SweeneyORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintAug 21, 2025

Time-Resolved Crystallography Reveals the Mechanisms of GTP hydrolysis for N-RAS and the Oncogenic Mutants G12C, G12V and Q61L

Guowu Lin, Paola Zinser Peniche, Xiaohong Zhou…·Guillermo A. Calero

This study uses time-resolved crystallography to capture GTP hydrolysis intermediates of N-RAS and oncogenic mutants, revealing shared and distinct reaction mechanisms.

3 citations

humanstructural biology

𝕏 PostBluesky

BiophysicsActa Crystallographica Section D Structural BiologyPeer-reviewedJan 18, 2024

Fragment-based screening targeting an open form of the SARS-CoV-2 main protease binding pocket

Chia‐Ying Huang, A. Metz, Roland Lange…·A. Mac Sweeney

This study identifies 29 fragment hits against SARS-CoV-2 main protease using X-ray crystallography, including two covalent binders, and shows crystal form affects fragment binding poses.

17 citations

experimental assaydrug response / drug discovery

𝕏 PostBluesky