A. Metz

This paper demonstrates an ADAR-mediated gene switch to control AAV-delivered gene expression by rescuing a premature termination codon via RNA editing, achieving tunable and clinically relevant therapeutic protein levels.

This study screens a natural product-like fragment library against PKA, identifies novel binders with unique chemical properties, and highlights their potential for improved selectivity and clinical success.

This study identifies 29 fragment hits against SARS-CoV-2 main protease using X-ray crystallography, including two covalent binders, and shows crystal form affects fragment binding poses.