Yuyu Li

This study identifies 12-HETE as a key metabolite in thoracic aortic dissection (TAD) that activates BLT2 receptors on macrophages, driving inflammation and VSMC phenotype switching, and shows that targeting this pathway can reduce TAD progression.

ProGeo-neo integrates genomic and proteomic data to improve neoantigen prediction by incorporating mass spectrometry validation and MHC binding prediction.

The paper introduces INeo-Epp, a method for predicting T-cell HLA class-I immunogenic epitopes and neoantigens using sequence-related amino acid features, achieving AUC scores of 0.81 and 0.78.