Mihaela E. Sardiu

The paper presents a computational model of the S. cerevisiae INO80 chromatin remodeling complex using integrative methods, revealing the structure and dynamics of key modules and introducing the INTEGRATOR workflow tool.

The paper identifies how the BRCA1-Y1853ter mutation alters protein interactions and cellular processes, suggesting gain-of-function effects in cancer.

The paper identifies distinct regions of SAP25 that recruit O-GlcNAc transferase, TET methylcytosine dioxygenases, and ubiquitin ligase/hydrolase activities to the Sin3/HDAC complex.

PerSEveML identifies persistent biomarker structures for rare events using an integrative machine learning approach and provides visualization tools for hypothesis generation.

This study uses a VCD-induced menopause mouse model to show that ovarian loss disrupts hepatic mitochondrial function and lipid homeostasis, increasing susceptibility to diet-induced obesity and steatosis.

The paper integrates bulk and single-cell RNAseq data to identify predictive gene networks and weak genes for ovarian cancer occurrence, survival, and clinical stage using netLDA, improving prediction performance.

The paper shows that disruptions in Pol I rRNA transcription specifically affect craniofacial development by causing NCC apoptosis and craniofacial anomalies in mice.

The paper applies the TopS method to flow cytometry data to identify rare cell populations in a human hematopoietic stem cell dataset.

The paper investigates how paralog switching affects Sin3 complex interaction networks in humans, revealing shared and distinct interactions between SIN3A and SIN3B.

The paper maps the WDR76 interactome using AP-MS and identifies key interactions with the CCT complex and other proteins, validating interactions with GAN and SIRT1.

The paper introduces TopS, a method to score protein interactions in proteomic datasets, revealing direct interactions and modules in human and yeast networks.

The paper identifies a novel protein complex, WHHERE, that regulates retinoic acid signaling and embryonic symmetry by controlling histone modifications and RNA Polymerase II recruitment.