Lauren A. Vanderlinden

scLASER simulates and detects time-dependent cellular dynamics in longitudinal studies, showing higher sensitivity than traditional methods in rare cell types and non-linear patterns.

The paper examines immune cell profiles around islet autoimmunity seroconversion in children with and without type 1 diabetes, finding differences in immune cell ratios that may reflect immune maturation disruptions.

The paper identifies genetic factors influencing opsin expression and cell fate in Drosophila R7 photoreceptors through GWAS and transcriptome analysis.

This study integrates GWAS and scRNA-seq to identify genetically relevant cell states in inflammatory diseases, finding scDRS outperforms scGWAS in capturing disease-relevant cellular heterogeneity.

The paper evaluates quantitative trait analysis methods for RNA expression in the HRDP to assess power and precision in identifying genetic variants associated with complex traits.

The paper identifies genes involved in R7 photoreceptor cell differentiation in Drosophila through genetic screens and analyzes their effects on Rh3 expression.