Hendrik Luesch

MGMG generates bioactivity-aware molecules using cell morphology and textual descriptions without target information, achieving comparable binding affinities to reference compounds.

This paper identifies Sec61β as essential for proteolytic processing and cell entry of Marburg virus glycoprotein, unlike Ebola virus, and suggests Sec61 as a therapeutic target.

The paper screens epigenetic small molecules to inhibit and reverse acinar ductal metaplasia in mouse pancreatic organoids, identifying several effective compounds with improved activity over TSA.