Raffaele Coppini

This study examines the long-term effects of mavacamten on sarcomere structure and function in hiPSC-derived cardiomyocytes from HCM patients, finding a biphasic reduction in force and structural remodeling.

The paper demonstrates that cardiac myocyte T-tubules can generate action potentials autonomously, distinct from those in the sarcolemma, using an all-optical method.