Leonardo Sacconi

This paper uses reinforcement learning to discover new mechanisms of reentry in excitable media, including subthreshold stimulation strategies that induce unidirectional propagation and reentry.

This paper uses polarized second-harmonic generation microscopy to analyze myosin states in hypertrophic cardiomyopathy, showing increased ON state fraction in mutated tissue.

This study examines the long-term effects of mavacamten on sarcomere structure and function in hiPSC-derived cardiomyocytes from HCM patients, finding a biphasic reduction in force and structural remodeling.

The paper introduces a no-shear imaging protocol for mesoSPIM light-sheet microscopy to improve imaging of thin tissue slices with reduced processing time and better axial resolution.

The paper develops a 3D-printed targeted sampling method to accurately identify and study arrhythmogenic sites in the mammalian heart after myocardial infarction.

The paper demonstrates that cardiac myocyte T-tubules can generate action potentials autonomously, distinct from those in the sarcolemma, using an all-optical method.

The paper uses calcium imaging to study neocortical dynamics during reach-to-grasp tasks in mice, revealing distributed and localized neural activity patterns.

This paper introduces a method to reconstruct whole-brain vasculature at the single capillary level using CLARITY, vascular staining, and light-sheet fluorescence microscopy.

This study demonstrates that Bessel beams improve the sensitivity and accuracy of functional imaging in light-sheet microscopy by reducing artifacts and enhancing detection of calcium transients and activity correlations.

This study shows rehabilitation promotes recovery of both structural and functional features of healthy neuronal networks after stroke in mice.