Author

Nisha Narayan

Wellcome/MRC Cambridge Stem Cell InstituteORCID 0000-0002-4106-2166Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Assay:CRISPR screen· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2

Frequent Co-Authors

Brian J.P. HuntlyiD· 3 shared Ainhoa Goñi‐SalaverriiD· 2 shared Cécile K. LopeziD· 2 shared David Lara‐AstiasoiD· 2 shared Diego AlignaniiD· 2 shared Francesco P. MarcheseiD· 2 shared George GiotopoulosiD· 2 shared Jake P. Taylor‐KingiD· 2 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCell Biology

Brian J.P. HuntlyORCID

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3 papers

Recent·Most cited

Cell BiologyNature CommunicationsPeer-reviewedNov 26, 2025

Identification of epigenetic regulators of fibrotic transformation in cardiac fibroblasts through bulk and single-cell CRISPR screens

Laura Pilar Aguado‐Alvaro, Nerea Garitano, Wolfgang Esser‐Skala…·David Lara‐Astiaso

The paper identifies epigenetic regulators of fibrotic transformation in cardiac fibroblasts using bulk and single-cell CRISPR screens and shows KAT5 inhibition reduces fibrotic responses in human fibroblasts.

11 citationstop 2%

humanCRISPR screen

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Cancer BiologyNature CommunicationsPeer-reviewedMay 20, 2025

Genetic or pharmacological inactivation of CREBBP sensitizes B-cell Acute Lymphoblastic Leukemia to Ferroptotic Cell Death upon BCL2 Inhibition

Alicia Garcia-Gimenez, Jonathan E. Ditcham, Dhoyazan Azazi…·Simon E. Richardson

This study identifies CREBBP mutations as a targetable vulnerability in B-ALL, showing that CREBBP inhibition sensitizes these cells to Venetoclax-induced ferroptosis.

19 citationstop 1%

humanbulk RNA-seq

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GenomicsbioRxivPreprintAug 11, 2022

Systematic functional screening of chromatin factors identifies strong lineage and disease dependencies in normal and malignant haematopoiesis

David Lara‐Astiaso, Ainhoa Goñi‐Salaverri, Julen Mendieta-Esteban…·Brian J.P. Huntly

This study uses CRISPR screens and Perturb-Seq to analyze 550 chromatin factors in haematopoiesis and AML, revealing lineage-specific roles and therapeutic implications.

1 citation

mouseCRISPR screen

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