Author

Cécile K. Lopez

Wellcome/MRC Cambridge Stem Cell InstituteORCID 0000-0003-4473-6311Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Brian J.P. HuntlyiD· 3 shared George GiotopoulosiD· 2 shared Nisha NarayaniD· 2 shared A Lopez· 1 shared Ainhoa Goñi‐SalaverriiD· 1 shared Albert KoulmaniD· 1 shared Alexis R. BarriD· 1 shared Alicia Garcia-GimeneziD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiochemistry

Brian J.P. HuntlyORCID

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3 papers

Recent·Most cited

BiochemistrybioRxivPreprintJun 10, 2025

Structural Identification of Major Molecular Determinants for Phosphotyrosine Recognition in Tyrosine Kinases Reveals Tumour Promoting and Suppressive Functions

Nuo Cheng, Luis R. Millán-Barea, Marc Creixell…·Michael B. Yaffe

The paper identifies molecular determinants for phosphotyrosine recognition in tyrosine kinases and shows their roles in tumor promotion and suppression.

1 citation

mouseproteomics

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Cancer BiologyNature CommunicationsPeer-reviewedMay 20, 2025

Genetic or pharmacological inactivation of CREBBP sensitizes B-cell Acute Lymphoblastic Leukemia to Ferroptotic Cell Death upon BCL2 Inhibition

Alicia Garcia-Gimenez, Jonathan E. Ditcham, Dhoyazan Azazi…·Simon E. Richardson

This study identifies CREBBP mutations as a targetable vulnerability in B-ALL, showing that CREBBP inhibition sensitizes these cells to Venetoclax-induced ferroptosis.

19 citationstop 1%

humanbulk RNA-seq

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GenomicsbioRxivPreprintAug 11, 2022

Systematic functional screening of chromatin factors identifies strong lineage and disease dependencies in normal and malignant haematopoiesis

David Lara‐Astiaso, Ainhoa Goñi‐Salaverri, Julen Mendieta-Esteban…·Brian J.P. Huntly

This study uses CRISPR screens and Perturb-Seq to analyze 550 chromatin factors in haematopoiesis and AML, revealing lineage-specific roles and therapeutic implications.

1 citation

mouseCRISPR screen

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