Matthias Hackl

This study shows that metabolic reprogramming of human macrophages using DASA-58 generates hybrid M1/M2 extracellular vesicles with pro-regenerative properties that enhance angiogenesis and osteogenesis.

The paper introduces a therapeutic strategy called castling to correct gene-expression imbalances by rewiring miRNA regulation using the TRIPLE genome-editing technology.

This paper introduces a Snorkel-tag system for affinity purification of extracellular vesicles using CD81 fused with tags and transmembrane domains, enabling non-destructive isolation and future applications in tracing and analyzing EVs.

The paper profiles miRNA expression during senescence and aging to identify potential circulating biomarkers of senescent cell burden in mice and humans.

The paper identifies small non-coding RNA biomarkers in extracellular vesicles from equine osteoarthritis models using small RNA sequencing and bioinformatics analysis.

This study compares extracellular miRNA profiles in lipedema and healthy adipose tissue, finding that sEV miRNAs are differentially regulated in lipedema.

This study identifies miR-146a as a key regulator of age-related bone loss, showing its role in controlling bone homeostasis through Wnt signaling and its potential as a therapeutic target.

This study examines miRNA changes in bone and blood during bisphosphonate and teriparatide treatment in an osteoporosis animal model, finding significant miRNA regulation linked to bone remodeling.