Author
Institute of Statistical Science, Academia SinicaORCID 0000-0002-4139-7089Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Petra Štěrbová, Hsin-Hung Lin, I‐Ping Tu, Wei‐Hau Chang
The paper designs truncated nsp8 proteins to inhibit SARS-CoV-2 replication by disrupting the nsp12-nsp7-nsp8 complex through competitive binding.
Jheng-Syong Wu, Yi‐Cheng Lin, Yi-Yu Wei…·Wei‐Hau Chang
The paper investigates the structural dynamics of the tWH domain in RNA polymerase III using smFRET and reveals multiple docking sites that explain its multi-functionality.
Luh Tung, Chung-Shu Yeh, Hsin-Hung Lin…·Tien‐Hsien Chang
This paper identifies a conserved unstructured region in Prp40 WW domains that facilitates their positioning to promote non-canonical intron splicing in yeast.
Hsin-Hung Lin, Chun-Hsiung Wang, Shih-Hsin Huang…·Wei‐Hau Chang
This study uses phase plate cryo-EM to reveal conformational diversity in therapeutic IgG, achieving sub-nanometer resolution of the Fab fragment.