Michèle Ramsay

This paper describes a study on participant engagement and feedback in microbiome projects in Africa, finding that culturally appropriate and timely feedback can improve trust and motivate health behaviors.

The paper analyzes epigenetic gene variants in African and European populations to find frequency differences, trait associations, and functional impacts.

The paper investigates why the 9p21.3 CAD risk locus fails to replicate in African ancestry cohorts, finding ancestry-specific LD and haplotype diversity explain the lack of association.

The paper introduces two fine-mapping methods to account for ancestral and environmental heterogeneity in GWAS, improving resolution of causal variants across diverse populations.

The paper examines how geography, ancestry, age, and sex influence the prevalence of somatic autosomal mosaic chromosomal alterations in blood across diverse populations.

The paper identifies a novel genetic locus OSBPL11 associated with vitamin D levels and cardiometabolic health in African populations through genome-wide analysis.

This study expands the human gut microbiome atlas of Africa by analyzing 1,803 women from four countries, revealing geographic and lifestyle-associated taxa and novel microbial genomes.

This paper introduces env-MR-MEGA, a meta-regression model that adjusts for environmental and ancestral heterogeneity in GWAS meta-analysis, improving association power.

This paper presents a blood regulatory variation map from Southern African populations, showing increased utility for interpreting African genetic studies.

This study conducts a GWAS on urinary albumin-to-creatinine ratio in Sub-Saharan African and non-resident African-ancestry populations, identifying two genome-wide significant loci and highlighting limited transferability of polygenic scores across populations.

This study identifies proteins and pathways linked to hypertension-associated albuminuria using urinary proteomics and machine learning in a South African cohort.

This study identifies genetic variants associated with smoking initiation and cessation in men of African ancestry, highlighting underrepresented populations in genetic research.

The paper analyzes G6PD variant distribution in sub-Saharan Africa and highlights potential risks of using chloroquine/hydroxychloroquine for COVID-19 due to G6PD deficiency.

This study investigates genetic substructure and demographic history of South African Bantu speakers using genome-wide data, revealing fine-scale population structure aligned with geography and linguistics.

The paper identifies a West African-associated regulatory variant with a strong female-specific effect on BMI and fat mass in Brazilian admixed populations.

This study characterizes ADME gene variation in sub-Saharan African populations, identifying novel variants and highlighting the need for tailored pharmacogenomic approaches.

This study analyzes runs of homozygosity in sub-Saharan African populations to uncover demographic history and health-related genetic variation.

The paper compares Runs of Homozygosity (ROH) detected from SNP array and low coverage whole genome sequence data to establish guidelines for combining datasets.