Haopeng Xiao

The paper identifies redox regulation of ATG5's Cys19 as critical for autophagy initiation under nutrient restriction in human cells and mice.

The paper identifies 90 structurally distinct STAND NTPase families in bacteria and archaea that recognize phage proteins, revealing their role in antiviral defense.

This paper identifies a druggable redox switch on SHP1 that controls macrophage inflammation by developing a covalent agonist targeting a specific cysteine residue.

This study identifies mitochondrial complex III-derived ROS as a key driver of immunometabolic changes in astrocytes that contribute to dementia pathology.

This study maps zinc-regulated cysteine sites in the human proteome, identifies cancer dependencies, and reveals a mechanism of zinc-induced cytotoxicity in lung cancers.