Author

Abigail G. Wolpe

University of VirginiaORCID 0000-0002-4169-3697Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1 Assay:proteomics· 1

Frequent Co-Authors

Brant E. IsaksoniD· 2 shared Alexander P. YoungiD· 1 shared Anastasia F. ThéveniniD· 1 shared Andrew K. J. BoyceiD· 1 shared Angela K. Best· 1 shared Anna Szagdaj· 1 shared Brooke L. O’DonnelliD· 1 shared Caitlin M. PaveleciD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersPhysiology

Brant E. IsaksonORCID

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2 papers

Recent·Most cited

PhysiologybioRxivPreprintJul 17, 2026

Pannexin 1 phosphorylation sites differentially modulate channel activity and physiological outcomes

Brooke L. O’Donnell, Luke S. Dunaway, Xuexin Zhang…·Brant E. Isakson

This study identifies that PANX1 Y198 phosphorylation mediates ATP release, driving β-adrenergic vasoconstriction in vascular smooth muscle cells.

DOI 10.64898/2026.07.12.738047

mouseexperimental assay

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PhysiologyCirculation ResearchPeer-reviewedJul 3, 2024

Pannexin 1 Channels Control Cardiomyocyte Metabolism and Neutrophil Recruitment During Non-Ischemic Heart Failure

Caitlin M. Pavelec, Alexander P. Young, Hannah L. Luviano…·Norbert Leitinger

This study shows that PANX1 deficiency in cardiomyocytes reduces glycolytic metabolism and protects against cardiac hypertrophy in non-ischemic heart failure by decreasing neutrophil recruitment.

33 citationstop 1%

mouseproteomics

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