Improving isoform-level eQTL and integrative genetic analyses of breast cancer risk with long-read RNA transcript assemblies
S. Taylor Head, Aryun Nemani, Yung-Han Chang…·Arjun Bhattacharya
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Fred Hutch Cancer CenterORCID 0000-0002-4173-7530Unclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
6 papers
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S. Taylor Head, Aryun Nemani, Yung-Han Chang…·Arjun Bhattacharya
Yung-Han Chang, Sean T. Bresnahan, S. Taylor Head…·Arjun Bhattacharya
This study identifies genetic risk mechanisms for six cancers by analyzing isoform-level expression data, finding more associations and greater heritability explained compared to gene-level analysis.
Minta Thomas, Yu‐Ru Su, Elisabeth A. Rosenthal…·Taiki Yamaji
This study improves polygenic risk scores for colorectal cancer by combining Asian and European ancestry data, enhancing risk prediction across diverse racial and ethnic groups.
James W. MacDonald, Tabitha A. Harrison, Theo K. Bammler…·Sara Lindström
The paper creates ancestry-specific linkage disequilibrium block maps for GRCh38, providing updated LD blocks for four populations.
Jeroen R. Huyghe, Tabitha A. Harrison, Stephanie A. Bien…·Rachel Pearlman
This study identifies 13 new genetic loci specific to proximal or distal colorectal cancer subtypes, revealing partly distinct genetic architectures for these tumor locations.
Nikos Papadimitriou, Niki L. Dimou, Konstantinos K. Tsilidis…·Neil Murphy
This study uses Mendelian randomization to show that higher physical activity levels are associated with lower risks of breast and colorectal cancer.