Steven W. Singer

This paper engineers Escherichia coli to use hydrogen and formate as energy sources, improving mevalonate production by 57.6% through metabolic decoupling.

This study investigates the functional plasticity of HCO3- uptake and CO2 fixation in C. necator H16 by testing endogenous and heterologous genes, showing that DIC transporters can support autotrophic growth and higher cell densities.

The paper expands the global RNA virome by five-fold, identifying new clades of RNA bacteriophages and revealing novel virus-host interactions.

The paper benchmarks computational metagenomics software using complex datasets, showing strengths and limitations in assembly, binning, and taxonomic profiling.