Kaelan Brennan

This study shows that SNAI1 and SNAI2 repressors tune enhancer activity by shifting chromatin states, affecting enhancer function and evolution.

The paper maps and interprets low-affinity transcription factor motifs in mESCs, showing they enhance chromatin accessibility and regulatory potential through cooperative interactions.

The paper uses deep learning to analyze chromatin accessibility in Drosophila embryos, revealing a two-phase process driven by pioneer TFs and enhancer-activating TFs.

The paper shows that Lola-I, a Drosophila zinc finger transcription factor, regulates promoter accessibility and paused Pol II during development, similar to enhancer regulation by pioneer factors.