ImmunologyThe Journal of Experimental MedicinePeer-reviewed
Neonatal microbiota colonization drives maturation of primary and secondary goblet cell mediated protection in the pre-weaning colon
Åsa Johansson, Mahadevan Venkita Subramani, Bahtiyar Yılmaz…·George M. H. Birchenough
This study shows that neonatal microbiota colonization sequentially programs primary and secondary goblet cell functions in the colon, with MyD88 and Duox2 playing key roles in mucus barrier and sentinel cell development.
6 citations