Nils C. Gassen

This study demonstrates the generation of functional human sensory neurons from iPSCs using NBI factors, showing their electrophysiological properties and disease relevance.

This study shows that Fkbp5 in noradrenergic neurons affects social behavior and norepinephrine dynamics in the basolateral amygdala, specifically in male mice.

This study identifies DNA methylation changes over time during antidepressant treatment in MDD, linking them to neuroplasticity and inflammation, and shows differences between responders and non-responders.

This study examines sex-specific effects of early life stress on fear memory and amygdala metabolism, revealing sex-dependent changes in glutamate and metabolic pathways.

This study shows that spermidine supplementation improves depression symptoms by enhancing autophagy and correcting polyamine imbalances in both humans and mice.

This study investigates the differential dynamics and roles of FKBP51 isoforms in response to glucocorticoids using in vitro models and human blood cells, highlighting their distinct functions and implications for targeted therapies.

This study shows that SKA2-regulated hyperactive secretory autophagy contributes to neuroinflammation and neurodegeneration in Alzheimer's disease.

This study shows that the FAAH C385A polymorphism exacerbates hormone-mediated feeding in mice under specific environmental conditions, affecting metabolic outcomes.

This study identifies FKBP51 as a molecular switch linking autophagy to metabolism in the mediobasal hypothalamus, showing its role in obesity regulation.

This study identifies HNK's mechanism of action by analyzing CSF proteome changes, showing its impact on glucocorticoid receptor signaling and potential upstream regulators.

This study investigates the role of Fkbp5 in the paraventricular nucleus of the hypothalamus in shaping the HPA axis stress response through genetic manipulations.

The paper investigates how psychiatric disease and aging affect FKBP5 expression in the human brain, identifying supragranular neurons as key targets.

This study shows that stress enhances secretory autophagy via FKBP51, leading to increased MMP9 secretion and proBDNF cleavage to mature BDNF, linking stress adaptation to psychiatric disorders.

The paper identifies FKBP5 epigenetic derepression by aging and stress as a driver of NF-kB-driven inflammation and cardiovascular risk through in vitro and cohort studies.