Bina Santoro

This study functionally classifies HCN1 variants in patients with neurodevelopmental disorders, finding genotype-phenotype correlations and potential therapeutic targets.

This paper shows that chemogenetic activation of hippocampal CA2 neurons increases seizure frequency and duration in a mouse model of epilepsy.

The paper examines how aging and Alzheimer disease affect perforant path input to hippocampal CA1 pyramidal neurons in mice, finding unique aging-related changes in excitatory responses.

The paper investigates inhibitory deficits in the hippocampal CA2 region of a mouse model of temporal lobe epilepsy, identifying reduced cholecystokinin-expressing interneurons and impaired inhibition.

This study investigates how HCN1 channels in parvalbumin-positive interneurons regulate GABA release in hippocampal CA1, showing that HCN1 enhances inhibitory transmission.

This study presents two genetic mouse models of HCN1 epileptic encephalopathy, showing seizure susceptibility and adverse drug responses, highlighting the need for tailored therapies.

This study investigates the role of hippocampal CA2 region in seizure generation in a mouse model of temporal lobe epilepsy, finding that enhanced excitability and reduced inhibition in CA2 contribute to seizure activity.