Author

Samuel J. Hobbs

Harvard UniversityORCID 0000-0002-4282-8813Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Genetics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 3 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Organism:mouse· 1

Frequent Co-Authors

Philip J. KranzuschiD· 3 shared Ilya А. OstermaniD· 2 shared Rotem SorekiD· 2 shared Adelyn E. RagucciiD· 1 shared Allen Lu· 1 shared Azita LeavittiD· 1 shared Carmel AvrahamiD· 1 shared David R. ShermaniD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersMicrobiology

Philip J. KranzuschORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

MicrobiologybioRxivPreprintMar 5, 2026

Phage protease enzymes activate CBASS antiphage immunity

Samuel J. Hobbs, Philip J. Kranzusch

The paper identifies phage protease activation of CBASS immunity by cleaving CD-NTase activation loops, revealing a conserved mechanism for antiviral defense.

1 citation

bacteria (other)proteomics

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MicrobiologyMolecular CellPeer-reviewedDec 31, 2024

A widespread family of viral sponge proteins reveals specific inhibition of nucleotide signals in anti-phage defense

Renee B. Chang, Hunter C. Toyoda, Samuel J. Hobbs…·Philip J. Kranzusch

The paper identifies Acb4, a viral protein that inhibits bacterial anti-phage defense by sequestering nucleotide signals.

22 citationstop 3%

E. colimouse

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GeneticsNaturePeer-reviewedNov 22, 2023

Phages overcome bacterial immunity via diverse anti-defense proteins

Erez Yirmiya, Azita Leavitt, Allen Lu…·Rotem Sorek

This study identifies anti-defense proteins in phages that inhibit bacterial immune systems like Gabija, Thoeris, and Hachiman.

144 citationstop 1%

bacteria (other)experimental assay

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Systems BiologybioRxivPreprintSep 27, 2018

Network stress test reveals novel drug potentiators in Mycobacterium tuberculosis

Shuyi Ma, Robert Morrison, Samuel J. Hobbs…·David R. Sherman

The paper identifies novel drug potentiators in Mycobacterium tuberculosis using a network-based genetic screening approach to uncover stress response adaptations to isoniazid.

2 citations

bacteria (other)statistical model

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