Luke E. Rogerson

This study shows that diltiazem enantiomers block Ca2+-influx in photoreceptors but do not prevent degeneration, challenging the role of Ca2+ in retinal degeneration.

The paper develops a method to image the entire inner plexiform layer of the retina at once, revealing response speed gradients in bipolar cells and isolating experimental batch effects.

The paper maps spatio-temporal patterns of calpain activity in retinal degeneration models, linking Ca2+ dysregulation to primary rod death and apoptosis to secondary cone loss.

The paper develops a Bayesian statistical pipeline for analyzing two-photon imaging data using Gaussian Process Regression to infer neural activity and guide experimental design.

The paper benchmarks spike rate inference algorithms for two-photon calcium imaging data and finds that top-performing algorithms show high correlation despite diverse approaches.

This study shows mouse horizontal cells process cone input locally, with dendritic Ca2+ signals reflecting cone opsin activation and chromatic preference, supporting local feedback shaping cone output.