Exo1-protected DNA nicks direct crossover formation in meiosis
Michael Gioia, Lisette Payero, Gianno Pannafino…·Eric Alani
This study shows Exo1 protects DNA nicks to promote meiotic crossover formation and distribution in budding yeast.
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Indian Institute of Science Education and Research ThiruvananthapuramORCID 0000-0002-4342-7501Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
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Michael Gioia, Lisette Payero, Gianno Pannafino…·Eric Alani
This study shows Exo1 protects DNA nicks to promote meiotic crossover formation and distribution in budding yeast.
Nadia M. V. Sampaio, V. P. Ajith, Ruth A. Watson…·Juan Lucas Argueso
The paper characterizes bursts of genome-wide loss-of-heterozygosity in budding yeast, showing non-independent mutation accumulation and systemic genomic instability.
Krishnaprasad G. Nandanan, Ajith V. Pankajam, Sagar Salim…·Koodali T Nishant
The paper investigates the in vivo localization of Msh5 during meiosis in yeast, showing its association with DSB hotspots, chromosome axis, and centromeres, and its role in promoting crossover formation.
Dev Ashish Giri, Ajith V. Pankajam, Koodali T Nishant, Durgadas P. Kasbekar
The paper investigates MSUD efficiency in different Neurospora crassa genetic backgrounds, finding that the standard Oak Ridge background exhibits unusually efficient MSUD compared to other backgrounds.
Nadia M. V. Sampaio, Aline Rodrigues-Prause, V. P. Ajith…·Juan Lucas Argueso
The paper identifies systemic genomic instability in yeast, showing non-independent accumulation of loss-of-heterozygosity events across multiple chromosomes.
Najla Al‐Sweel, Vandana Raghavan, Abhishek Dutta…·Eric Alani
The paper identifies mlh3 alleles with distinct separation of function phenotypes in meiosis and DNA mismatch repair, revealing the role of protein-protein interactions in regulating Mlh1-Mlh3 activity.