Vandana Raghavan

This study shows Exo1 protects DNA nicks to promote meiotic crossover formation and distribution in budding yeast.

This paper shows that a mutation in the endonuclease domain of MLH3 in mice disrupts crossover formation during meiosis but allows partial CO generation compared to a full null mutation.

The paper identifies mlh3 alleles with distinct separation of function phenotypes in meiosis and DNA mismatch repair, revealing the role of protein-protein interactions in regulating Mlh1-Mlh3 activity.