Sahand Hormoz

The paper models how short-range adhesion and long-range attraction in gastruloids lead to robust axis formation, supported by experimental validation.

This paper discovers and characterizes SH6, a small molecule degrader of ZBTB7A that increases fetal hemoglobin expression in erythroid cells and shows therapeutic potential for β-hemoglobinopathies.

scAI-SNP infers ancestry from single-cell data using ancestry-informative SNPs, showing robustness across diverse tissues and modalities.

This paper analyzes how model mismatches affect the inference of selection coefficients and mutation timing in population genetics, showing that time of onset is sensitive to assumptions about reproductive variance and generations.

This study shows LEDGF is recruited to promoters by MLL1 and recruits RNA Pol II, facilitating HIV-1 integration across gene bodies.

This paper introduces ODeGP, a Gaussian Process-based method for detecting oscillations in time series, and shows it outperforms existing methods in detecting weak and non-stationary rhythms in qPCR data.

SComatic detects somatic mutations in single-cell RNA-seq and ATAC-seq data without bulk DNA sequencing, achieving higher precision than existing methods.

This study generates human paraxial mesoderm organoids that form somite-like structures in vitro, enabling analysis of human spinal cord development.

The paper estimates Riemannian curvature of image and scRNA-seq data manifolds using extrinsic differential geometry, revealing curvature in scRNA-seq datasets.

The paper introduces a CRISPR/Cas9 mouse line (CARLIN) to simultaneously track lineage histories and gene expression in single cells, revealing clonal bottlenecks in hematopoietic stem cells.