Author

Deniz Durmusoglu

North Carolina State UniversityORCID 0000-0002-4450-509XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Synthetic Biology· 3 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 2 Assay:proteomics· 2 Organism:yeast· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Nathan C. CrookiD· 4 shared Ibrahim S. Al’AbriiD· 3 shared Chase L. BeiseliD· 2 shared Adriana San‐MigueliD· 1 shared Andrew S. Clark· 1 shared Carmen SandsiD· 1 shared Constantinos PatiniosiD· 1 shared Daniel J. HalleriD· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersSynthetic Biology

Nathan C. CrookORCID

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4 papers

Recent·Most cited

Synthetic BiologyMolecular CellPeer-reviewedJun 26, 2024

A cell-free transcription-translation pipeline for recreating methylation patterns boosts DNA transformation in bacteria

Justin M. Vento, Deniz Durmusoglu, Tianyu Li…·Chase L. Beisel

IMPRINT uses cell-free transcription-translation to methylate DNA, bypassing bacterial restriction and improving transformation efficiency in diverse bacteria.

18 citationstop 4%

bacteria (other)experimental assay

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BioengineeringACS Synthetic BiologyPeer-reviewedMay 24, 2024

Programming Probiotics: Diet-responsive gene expression and colonization control in engineered S. boulardii

Deniz Durmusoglu, Daniel J. Haller, Ibrahim S. Al’Abri…·Nathan C. Crook

This study engineers S. boulardii to control gene expression and gut residence time via diet-responsive systems, enabling precise therapeutic delivery in the mouse gut.

16 citations

mouseproteomics

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Synthetic BiologybioRxivPreprintDec 30, 2022

Improving Therapeutic Protein Secretion in the Probiotic Yeast Saccharomyces boulardii using a Multifactorial Engineering Approach

Deniz Durmusoglu, Ibrahim S. Al’Abri, Taufika Islam Williams…·Nathan Crook

This paper improves therapeutic protein secretion in Saccharomyces boulardii using genetic modifications and proteomics, achieving >10-fold higher secretion of a neutralizing peptide.

1 citation

yeastprotein sequence

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Synthetic BiologybioRxivPreprintJan 22, 2020

Establishing Probiotic Saccharomyces boulardii as a Model Organism for Synthesis and Delivery of Biomolecules

Deniz Durmusoglu, Ibrahim S. Al’Abri, Scott P. Collins…·Nathan Crook

This paper characterizes genetic elements in Saccharomyces boulardii to enable engineered biomolecule synthesis and delivery in the gut, showing tunable gene expression and colonization dynamics.

5 citations

yeastproteomics

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