Saharon Rosset

The paper identifies a period-3 base frequency pattern in DNA mixtures and develops an alignment-free algorithm to uncover its origin, showing it results from sequence-dependent fragment formation rather than intrinsic DNA bias.

The paper introduces a method for fast and robust collective posterior inference from multiple noisy replicates, achieving state-of-the-art accuracy and efficiency.

The paper shows glycolysis produces ATP faster per gram of protein than respiration in E. coli, yeast, and mammalian cells, explaining the Warburg Effect as an optimization of energy production rate under proteome constraints.

The paper introduces a variance components method to estimate gene-environment interaction heritability in complex traits using UK Biobank data, finding significant GxE effects for several trait-environment pairs.

The paper benchmarks two methods for detecting cell-type-specific differential DNA methylation, finding TCA superior to CellDMC and discussing best practices for cell-type resolution analysis.

The paper demonstrates a method to infer cell-type-specific DNA methylation from bulk data, revealing novel associations with leukocyte composition and rheumatoid arthritis.

This paper evaluates methods for estimating heritability and genetic correlation in case-control studies, finding that PCGC-s accurately handles non-genetic risk factors and provides unbiased estimates for schizophrenia and bipolar disorder.

RL-SKAT improves the accuracy of score tests for heritability and set-based genetic association by calculating exact p-values, avoiding the inflation or deflation of p-values seen in traditional methods.

This paper introduces ALBI, a method for constructing accurate confidence intervals for heritability estimates using linear mixed models, addressing biases in existing approaches.