Maxime De Waegeneer

The paper identifies TZAP as a developmental regulator of mitochondrial homeostasis critical for activity-dependent synaptic connectivity in Drosophila.

The paper creates a single-cell transcriptomic atlas of the adult fruit fly, identifying over 250 cell types and analyzing gene signatures and sexual dimorphism across tissues.

The paper identifies regulatory regions and gene regulatory networks in Drosophila brain cell types using chromatin accessibility and transcriptome data.

The paper identifies and characterizes enhancer activity in melanoma cell states using MPRA and DeepMEL2, showing AP-1 drives MES enhancers and SOX/MITF influence MEL enhancers.

The paper spatially integrates single-cell transcriptomics and epigenomics data to identify enhancers and gene regulatory relationships in Drosophila eye-antennal disc.

The paper identifies an intermediate cell state in melanoma through single-cell RNA-seq and ATAC-seq, revealing a gene regulatory network that governs phenotype switching and potential therapeutic targets.

This study creates a single-cell transcriptome catalogue of the Drosophila brain across its lifespan, revealing regulatory erosion and identifying novel neuronal states linked to ageing.