Steven Chu

This study uses smFRET to show that opioid ligands modulate Gi protein conformational dynamics, with higher-efficacy agonists promoting open, low-nucleotide-affinity states.

This study reveals that membrane phosphoinositides allosterically regulate β-arrestin dynamics, enabling engagement with minimally phosphorylated GPCRs.

The paper examines age-related changes in gene expression noise across multiple cell types and tissues using single-cell transcriptomics, identifying thousands of genes with significant noise changes.