Sheikh Nizamuddin

This study shows that SMAD4 MH2 mutations in colorectal cancer impair CREBBP/EP300 recruitment and TGF-β-induced transcription, explaining their loss-of-function effects.

This study shows TAF2's intrinsically disordered region drives condensation in nuclear speckles, recruiting SRRM2 to TFIID and affecting alternative splicing.

The paper identifies MEN1 missense mutations that disrupt menin-MLL and menin-JunD interactions, highlighting their role in pathogenicity.