Jan Grzegorzewski

This study compares lobular geometry and CYP450 zonation across four species using whole slide imaging, identifying species differences and determining the minimum number of lobules needed for statistical analysis.

This paper develops a PBPK model of talinolol to study P-gp function and its impact on pharmacokinetics under various conditions.

This study develops a PBPK model to assess CYP2E1 activity using chlorzoxazone, showing how ethanol consumption, abstinence, and liver impairment affect its metabolism.

This paper introduces a method to encode dynamic FBA models in SBML, enabling exchange and simulation of hybrid models across tools.

This paper uses computational modeling to analyze how physiological and anthropometric factors affect indocyanine green elimination in liver function tests.

PK-DB provides an open database of pharmacokinetics data from clinical and pre-clinical studies, enabling meta-analysis and integration with computational models for individualized and stratified modeling.