Author

Joseph D. Closson

The Graduate Center, CUNYORCID 0000-0002-4618-3119Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:structural biology· 1

Frequent Co-Authors

Kevin H. GardneriD· 2 shared Leandro Pimentel MarcelinoiD· 2 shared Xingjian XuiD· 2 shared Denize C. FavaroiD· 1 shared Eta A. IsiorhoiD· 1 shared Jason S. NagatiiD· 1 shared Joseph A. GarciaiD· 1 shared Lillian T. ChongiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

Kevin H. GardnerORCID

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2 papers

Recent·Most cited

BiochemistryProceedings of the National Academy of SciencesPeer-reviewedApr 28, 2026

Context-Dependent Variability Of HIF Heterodimers Influences Interactions With Macromolecular And Small Molecule Partners

Joseph D. Closson, Xingjian Xu, Meiling Zhang…·Kevin H. Gardner

This study investigates how context-dependent variability in HIF heterodimers affects their interactions with DNA, small molecules, and coactivators, revealing a novel 'dimer-of-heterodimers' structure.

DOI 10.1073/pnas.2514042123

humanstructural biology

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BiochemistryJournal of Biological ChemistryPeer-reviewedJul 24, 2024

Identification of Small Molecule Ligand Binding Sites On and In the ARNT PAS-B Domain

Xingjian Xu, Joseph D. Closson, Leandro Pimentel Marcelino…·Kevin H. Gardner

The paper identifies ligand-binding sites on and within the ARNT PAS-B domain using NMR, MD simulations, and ensemble docking, revealing distinct binding modes for three small molecules.

11 citations

experimental assaydrug response / drug discovery

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