Fergal J. Duffy

This study shows that subunit vaccination provides better protection than BCG in Mtb-exposed individuals, supported by mouse models and human data.

This study shows that ferroptosis, a form of cell death, is enhanced by a virulent Mtb strain, SA161, and inhibiting it reduces bacterial spread in mice.

This study uses single-cell RNA sequencing to identify immune dynamics distinguishing protection from susceptibility to tuberculosis in mice.

This study shows that prior immunity influences tuberculosis lesion structure by modulating neutrophil and T cell responses, leading to different pathological outcomes.

The paper identifies gene pathways associated with neutrophil and platelet responses that are activated up to six months before TB diagnosis in whole blood.

The paper develops a 10-gene random forest signature to predict TB and HIV status and distinguishes TB/HIV co-infection from other conditions with high accuracy.