Thomas Fröhlich

The paper shows that inhibiting miR-128-3p improves muscle function and reduces aging-related pathology in multiple models.

This study shows Netrin-1 supports naive pluripotency in hESCs by modulating epigenetic and signaling pathways, with effects dependent on culture conditions.

This study shows microplastics impair predator-induced defenses in Daphnia across behavioral, morphological, and molecular levels by disrupting kairomone-mediated plasticity.

This study presents a phosphoproteomic workflow for Daphnia magna to investigate molecular effects of pollution, identifying 3,532 phosphorylation sites across 1,329 phosphoproteins.

This study identifies snR37 as a bifunctional H/ACA snoRNP that both pseudouridylates rRNA and scaffolds ribosome assembly during pre-60S intermediate formation.

The paper identifies gene expression patterns and regulatory mechanisms in the calcareous sponge Sycon ciliatum that parallel those in stony corals, suggesting convergent evolution in biomineralization.

The paper identifies gHgLgO as the central player in HCMV infectivity by showing its role in HSPG binding and infectivity, challenging previous views on gB and gMgN complexes.

This study identifies early impairments in satellite cells of a porcine DMD model using multi-omics analysis, showing intrinsic genetic defects rather than environmental factors.

This paper develops decellularized extracellular matrix hydrogels for bio-fabricating female reproductive tissues, showing high biocompatibility, structural accuracy, and cell viability without growth factors.

The paper uses single-cell RNA sequencing and proteomics to analyze pig blastocyst development, identifying new cell subpopulations and regulatory networks.

This study shows that AAV1.SERCA2a gene therapy improves heart function and reduces arrhythmia in a pig model of Duchenne muscular dystrophy.

The paper detects microplastics in women's and cows' follicular fluid and shows polystyrene microplastics impair bovine oocyte maturation in vitro.

The paper identifies Otu2's role in deubiquitinating eS7 on recycled 40S ribosomal subunits to reset translation, revealing structural mechanisms for this process.

This study investigates the distinct roles of maternally-inherited mRNAs and proteins in fish egg development, showing they contribute to neurodevelopment and immune protection respectively.

This study reveals how SARS-CoV-2 Nsp1 protein inhibits host translation and immune responses by binding ribosomes and blocking mRNA entry.