Jesús M. Santiago-Borges

This study identifies two monoclonal antibodies against FimH adhesin that protect mice from E. coli UTI by sterically blocking FimH function, offering an antibiotic-sparing treatment strategy.

This study shows that SLPI protects against acute UTI in mice and suggests SLPI is regulated in response to uropathogen exposure in women.

This study identifies Notch signaling in the distal germline as a root cause of reproductive aging in C. elegans by showing that ectopic expression of the Notch effector gene SYGL-1 delays aging.