PhysiologybioRxivPreprint
Upstream alternative polyadenylation in SCN5A produces a short transcript isoform encoding a mitochondria-localized NaV1.5 N-terminal fragment that influences cardiomyocyte respiration
Nathan H. Witmer, Jared M. McLendon, Colleen S. Stein…·Ryan L. Boudreau
This study identifies an upstream alternative polyadenylation event in SCN5A that generates a short transcript encoding a mitochondria-localized NaV1.5 N-terminal fragment, which affects cardiomyocyte respiration.