John W. Elrod

The paper shows that modifying ionic interactions with phospholipids prevents hypoxic adaptation by preserving inner mitochondrial membrane fluidity and CoQ transfer.

The paper introduces K9HeartCircDB, a database of circRNAs in canine heart tissue under tachypacing-induced HF, providing tools for circRNA exploration and validation.

This study shows that reducing neuronal mitochondrial calcium uptake in AD mouse models decreases pathology, synaptic dysfunction, and cognitive decline.

The paper identifies YAP1 and QSER1 as key regulators of developmental signaling pathways in the mammalian epiblast, showing their role in maintaining pluripotency and preventing excessive differentiation.

This study shows TPC2 activation enhances lysosome-mitochondria calcium transfer, affecting mitochondrial function and stress responses, with implications for neuroprotection in stroke.

This study examines changes in organelle apposition in human heart failure cardiomyocytes, finding increased distances between mitochondria and sarcoplasmic reticulum/lipid droplets, along with altered molecular tethers.

This study identifies TMEM65 as a regulator of NCLX-dependent mitochondrial calcium efflux, showing its role in preventing calcium overload and cell death in excitable tissues.

This study identifies IL-13 as a driver of increased mitochondrial mass in esophageal keratinocytes, impairing squamous cell differentiation and contributing to eosinophilic esophagitis.

The paper uses systems biology to identify mitochondrial dysfunction and metabolic disruptions as key factors in HFpEF using a rat model.

This study identifies an upstream alternative polyadenylation event in SCN5A that generates a short transcript encoding a mitochondria-localized NaV1.5 N-terminal fragment, which affects cardiomyocyte respiration.