Colin Davenport

Wochenende is a modular pipeline for shotgun metagenome analysis that improves alignment filtering and visualization for microbial taxonomy and functional gene analysis.

The paper analyzes mtDNA variants in iPSCs and finds that culture expansion selects against harmful mitochondrial mutations, while reprogramming and differentiation do not significantly alter mtDNA heteroplasmy.

The paper shows that reprogramming enriches for mutations in cancer-associated genes in hiPSCs, potentially increasing tumor risk.