Ulrich Martin

This study uses patient-derived iSMCs to uncover new mechanisms of PAH and sotatercept's effects beyond its known anti-proliferative actions.

This study transplants human iPSC-derived cardiomyocyte aggregates into non-human primates with myocardial infarction, showing efficient engraftment and functional recovery with lower cell doses than previous single-cell approaches.

This study identifies aberrant cell populations in RAS lungs using snRNA-seq and histology, revealing a fibrotic niche composed of specific cell types with potential therapeutic targets.

The paper uses cerebral organoids from patients with actin mutations to show that altered cleavage plane orientation in ventricular zone progenitors leads to microcephaly.

This study identifies human-specific morphoregulatory signatures in basal radial glia that drive neocortex evolution through comparative chromatin and transcriptional profiling.

This study shows that primate-specific EPIREGULIN expression enhances basal progenitor proliferation in the developing neocortex, contributing to increased brain size across species.

The paper analyzes mtDNA variants in iPSCs and finds that culture expansion selects against harmful mitochondrial mutations, while reprogramming and differentiation do not significantly alter mtDNA heteroplasmy.

This study introduces a biallelic inducible Caspase9 suicide gene system in hiPSCs to prevent drug-resistant escapees, showing no escapees in biallelic cells versus rare escapees in monoallelic cells.

The paper shows that reprogramming enriches for mutations in cancer-associated genes in hiPSCs, potentially increasing tumor risk.

The paper reanalyzes single-cell transcriptomic data and in situ stains to reveal the presence of a transcriptomically homologous inner cell mass in human blastocysts, highlighting unique developmental and evolutionary features.