Author

Poorva Sandlesh

Roswell Park Comprehensive Cancer CenterORCID 0000-0002-4775-7188Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Cancer Biology· 1 Molecular Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Alfiya F. SafinaiD· 2 shared Jianmin WangiD· 2 shared Katerina V. GurovaiD· 2 shared Abhishek Venketeswaran· 1 shared Aimee B. StablewskiiD· 1 shared Alex M. LiiD· 1 shared Andrei V. GudkoviD· 1 shared Anette U. DuensingiD· 1 shared

Activity by Year

2017-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersSystems Biology

Alfiya F. SafinaORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintApr 9, 2024

All-trans retinoic acid induces durable tumor immunity in IDH-mutant gliomas by rescuing transcriptional repression of the CRBP1-retinoic acid axis

Aparna Rao, Xiaoran Zhang, Anthony Richard Cillo…·Nduka Amankulor

This study shows that all-trans retinoic acid (ATRA) improves immune response in IDH-mutant gliomas by restoring the RA pathway, leading to tumor regression in mouse models and a clinical trial for human patients.

2 citations

mousehuman

𝕏 PostBluesky

Systems BiologybioRxivPreprintJun 21, 2021

FACT-mediated maintenance of chromatin integrity during transcription is essential for viability of mammalian stem cells

Imon Goswami, Poorva Sandlesh, Aimee B. Stablewski…·Katerina V. Gurova

This study shows that FACT is essential for maintaining chromatin integrity during transcription in mammalian adult stem cells, and its loss leads to lethality due to stem cell failure.

DOI 10.1101/2021.06.21.449309

mouseChIP-seq

𝕏 PostBluesky

Molecular BiologybioRxivPreprintJun 28, 2017

Transcription of Repeats Activates INterferon (TRAIN) in response to chromatin destabilization induced with anti-cancer small molecule

Katerina I. Leonova, Alfiya F. Safina, Elimelech Nesher…·Katerina V. Gurova

The paper shows that chromatin destabilizing drugs like curaxin induce an interferon response (TRAIN) through repeat transcription, independent of p53 status, and may prevent cancer by eliminating epigenetically unstable cells.

DOI 10.1101/142471

experimental assay

𝕏 PostBluesky