Simon P. Jochems

This study evaluates nasal immune cell sampling methods and antigen-specific T cell detection using cryopreserved nasal swabs, finding that flocked swabs yield more cells and cryopreservation preserves functional T cells.

This study shows that ageing reduces tissue-resident memory T cells in the upper airway, linked to impaired epithelial-immune crosstalk and reduced TGF-β signaling.

This study maps SES-related immune diversity using flow cytometry, finding lower SES associates with downregulated surface proteins and upregulated immune checkpoints.

The study uses spectral flow cytometry to analyze immune function across populations, revealing geographical differences and TLR8's role in mRNA vaccine responses.

This study integrates mass cytometry data from diverse populations to identify immune signatures associated with rural living, finding shared differences in lymphocyte and innate immune cell characteristics.

The paper evaluates and re-annotates DNA methylation probes from two microarrays for use in two nonhuman primate species, identifying reliable probes for high-throughput methylation analysis.

This study examines age-related changes in nasal mucosal immune composition and function, finding reduced granulocytes and T cells in young children and older adults, and links pneumococcal colonization to inflammation.

This study uses a human challenge model to show that nasal colonization by Streptococcus pneumoniae can take up to 24 hours and identifies two distinct clearance mechanisms involving neutrophils.