Nancy E. Kleckner

The paper reveals a two-tiered crossover patterning mechanism in budding yeast meiosis, with mechanical forces and Pch2/TRIP13 modulating triad components.

The paper uses 4D fluorescence imaging to study homolog juxtaposition during meiosis in budding yeast, revealing rapid and dynamic processes involving motion and crossover interference.

The paper introduces a new measure of genome-wide genetic shuffling that accounts for crossover positions and Mendel’s second law, showing it is nearly maximal in humans due to independent assortment.

The paper shows that DNA sequence homology can induce cytosine-to-thymine mutations via a heterochromatin-related pathway in Neurospora crassa.

The paper introduces a MATLAB program that implements the beam-film model to simulate and analyze meiotic crossover patterns.