Author

Jae‐Hyuck Shim

University of Massachusetts Chan Medical SchoolORCID 0000-0002-4947-3293Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pharmacology & Toxicology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Organism:C. elegans· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Yeon-Suk Yang· 2 shared Abigail M. O’Connor· 1 shared Afreen Anwar· 1 shared Aijaz Ahmad JohniD· 1 shared Ali Asghar ShahiD· 1 shared Anastasia KhvorovaiD· 1 shared Ashley SummersiD· 1 shared Bruktawit MaruiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersPharmacology & Toxicology

Yeon-Suk Yang

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Pharmacology & ToxicologyNucleic Acids ResearchPeer-reviewedNov 26, 2025

Potent and durable gene modulation in heart and muscle with chemically defined siRNAs

Hassan H. Fakih, Clemens Lochmann, Rosemary Gagnon…·Anastasia Khvorova

This study develops chemically defined siRNAs for durable gene modulation in muscle and heart, showing long-term silencing and functional benefits with minimal toxicity.

9 citations

mouseexperimental assay

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Pharmacology & ToxicologyNew BiotechnologyPeer-reviewedJun 24, 2024

Nucleic Acid Aptamers Protect Against Lead (Pb(II)) Toxicity

Afreen Anwar, Solimar Ramis de Ayreflor Reyes, Aijaz Ahmad John…·Natalie G. Farny

This study shows DNA and RNA aptamers protect C. elegans and human cells from lead toxicity by mitigating reproductive, behavioral, and osteogenic effects.

4 citations

C. eleganshuman

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Molecular BiologyeLifePeer-reviewedAug 17, 2022

Impaired ERK MAPK activation in mature osteoblasts enhances bone formation via the mTOR pathway

Jung‐Min Kim, Yeon-Suk Yang, Jaehyoung Hong…·Jae‐Hyuck Shim

The paper shows that inhibiting ERK in mature osteoblasts enhances bone formation through mTOR pathway activation, revealing a dual role of ERK in osteoblast differentiation.

69 citationstop 4%

mousestatistical model

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