Manuel Colucci

This study shows that increasing hydrogen sulfide in aged mice reduces vascular senescence and reverses vascular remodeling.

This study identifies phenylacetate (PAA), a gut microbiota metabolite, as a driver of vascular niche senescence and atherosclerosis in mice through IL-6-Notch1 signaling.

This study shows that gut microbiota-dependent phenylacetic acid (PAA) increases endothelial cell senescence and impairs angiogenesis in aging, with acetate able to reverse these effects.