Paulina Podszywalow‐Bartnicka

The paper quantifies transcriptional readthrough in CML cells after imatinib treatment and shows it precedes alternative splicing changes and resistance development.

This study identifies Polθ as a therapeutic target in DNMT3A-mutated leukemia by showing its essential role in DNA repair and replication fork restart, and demonstrates that its inhibition enhances standard therapies.

This study investigates how intron RNA structure affects gene expression using reporter assays and machine learning, finding that base pairing significantly modulates mRNA and protein levels.

This paper develops a high-throughput microfluidic system to generate reproducible 3D leukemia microenvironments for drug testing, showing that stroma-leukemia interactions protect cells from drug-induced cytotoxicity.