Benoit J. Van den Eynde

This study identifies Gpr149 as an endogenous antigen in SB28 glioblastoma that can be targeted by vaccination to induce protective immunity against checkpoint inhibitor-refractory tumors.

This study shows that CXCR3 on transferred T cells enhances the effectiveness of combining adoptive T-cell therapy with viral-vector vaccines in solid tumors.

This study shows that chemotherapy, specifically CarboTaxol, synergizes with cancer vaccines and anti-PD-1 to improve tumor control and survival by expanding stem-like TCF1+CD8+ T cells.

This study shows that viral vector vaccination induces brain-resident memory T cells that effectively combat glioblastoma, offering a potential therapeutic strategy.

The paper identifies a CK2-FBXW11 kinase-E3 ubiquitin ligase cascade that regulates TDO2 stability through Trp-dependent phosphorylation shielding.